It is generally used in the synthesis of pharmaceutical intermediates, such as α-bromo-p-hydroxyacetophenone, choleretic drugs, antipyretic and analgesic medications, and other compounds.
Products Description
A phenolic ketone with molecular formula C₈H₈O₂, containing both a phenolic hydroxyl and a carbonyl group
Exists as white crystalline powder, moderately soluble in water, freely soluble in organic solvents
Exhibits typical phenol properties (weak acidity, oxidation susceptibility) and ketone reactivity
Good thermal stability with melting point 108–111°C
Friedel–Crafts Acylation: Most common industrial route (phenol + acetic acid/acetic anhydride)
Biocatalytic Synthesis: Emerging enzymatic/microbial methods for greener production
Extraction: From natural sources like Artemisia plants (less common industrially)
Pharmaceuticals: Key intermediate for β-blockers (atenolol, metoprolol), asthma drugs, and analgesics
Cosmetics: Preservative booster (extends efficacy of parabens), anti-inflammatory agent in skincare
Chemical Synthesis: Building block for fragrances, liquid crystals, and agrochemicals
Current Market: Steady demand (~5–7% annual growth) driven primarily by pharmaceutical sector
Regional Production: China dominates global supply (>65% capacity)
Future Trends:
Growing demand for high-purity pharmaceutical-grade material
Shift toward greener biocatalytic processes
Expanding applications in cosmetics as natural preservative enhancer
Challenges: Price volatility of phenol feedstocks, tightening environmental regulations on traditional synthesis
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